BOTH EZH2 AND JMJD6 REGULATE CELL CYCLE GENES IN BREAST CANCER

Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer

Abstract Background Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer.Here we explore potential partners that coregulate gene expression, to understand additional pathways that are activated by higher amounts of JMJD6.Methods We used Gene Set Enrichment Analysis (GSEA) data to 1/6th Ac

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Helicobacter pylori in Health and Disease: Its Contribution to Gastrointestinal Disorders and Systemic Metabolic Effects

Helicobacter pylori is one of the most common human infections worldwide and it is estimated that more than half of global population is affected.This microorganism induces oxidative stress in gastric mucosa and causes chronic gastritis, duodenal peptic ulcer, gastric cancer, and as reasonably suspected a number of extragastric diseases [1,2].Our r

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Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer

Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has been a milestone in the history of KRAS mutant tumors; however, therapeutic resistance limits

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